Arithmetic Abilities in Children With 22q11.2DS (ARITH22)

Hôpital le Vinatier

Status: Terminated

Conditions: 22q11.2 Deletion Syndrome

Treatments: Behavioral: Magnitude comparison tasks and neuropsychological testing

Study type: Interventional

Funder types: Other

Identifiers

NCT04373226

2020-A00102-37

Details and patient eligibility

About

The study ARITH22 will investigate the role of visuo-spatial attention on arithmetic abilities of children with 22q11.2 deletion syndrome.

Full description

Children with 22q11.2 deletion syndrome often have arithmetic learning disability because of magnitude representation impairment. Previous works suggested that magnitude representation impairment could be a result of endogenous visuo-spatial attention dysfunction in 22q11.2DS. Nevertheless this relationship is still poor explored. The influence of visuo-spatial abilities on arithmetic achievement could also be modulated by developmental age. The study ARITH22 will test these hypotheses thanks to magnitude comparisons tasks, in children with 22q11.2 deletion syndrome and matched children without developmental disease.

Enrollment: 41 patients

Sex: All

Ages: 4 to 11 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of 22q11.2 deletion syndrome or no developmental disease
• Aged from 4 to 11 years old
• French language

Exclusion criteria

• Diagnosis of intellectual deficiency according to DSM 5 criteria
• Drug prescribed for somatic condition that could influence cerebral functioning

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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41 participants in 2 patient groups

22q11.2DS

Experimental group

Description:

Children aged from 4 to 11 years old with 22q11.2 deletion syndrome

Treatment:

Behavioral: Magnitude comparison tasks and neuropsychological testing

NON22q11.2DS

Active Comparator group

Description:

Children aged from 4 to 11 years old without developmental disease

Treatment:

Behavioral: Magnitude comparison tasks and neuropsychological testing