Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery (Mitra-VT)

Karolinska Institute

Status: Enrolling

Conditions: Mitral Regurgitation; Mitral Valve Prolapse; Ventricular Tachycardia

Treatments: Procedure: Mitral valve surgery

Study type: Observational

Funder types: Other

Identifiers

NCT06255457

SG-23-0142-B (Other Grant/Funding Number)

987010 (Other Grant/Funding Number)

2-116/2023 (Other Grant/Funding Number)

VR 2022-01472

20220524 (Other Grant/Funding Number)

Details and patient eligibility

About

Study objectives:

• To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline to 6 months after surgery
• To characterize the molecular landscape of arrhytmogenic MVP

Study design:

-Prospective explorative observational study

Study population:

-90 patients with arrhytmogenic MVP and without arrhytmogenic MVP (controls) eligible for mitral valve surgery for mitral regurgitation will be enrolled. All patients will be evaluated with cardiac magnetic resonance (CMR) imaging and continuous seven day arrhythmic monitoring before and at 6 months after mitral valve surgery

Full description

Prospective explorative observational study in which the impact of mitral valve surgery for mitral regurgitation on ventricular arrhytmias and CMR imaging biomarkers will be examined in patients with arrhythmogenic MVP compared to those without arrhythmogenic MVP (controls). Molecular phenotyping of endocardial biopsies in patients with and without arrhythmogenic MVP will be performed as well as molecular phenotyping of the myxomatous disease in explanted valves by means of deep RNA single cell sequencing. Using CMR in 90 patients with MVP before and 6 months after mitral valve surgery, the presence and type (reversible vs irreversible) of papillary muscle and cardiac fibrosis will be characterized. To assess change in ventricular arrhytmic burden after surgery, patients will undergo continuous seven day monitoring with E-patch at baseline and at 6 months after mitral valve surgery. During surgery, explanted mitral valves (in patients undergoing replacement) as well as endocardial biopsies will be collected.

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

• Age 18 and over
• Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care

Exclusion criteria

• Secondary mitral regurgitation
• Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)
• Co-existing moderate or severe aortic valve disease
• Congenital heart disease
• Inherited or acquired cardiomyopathy
• Non-incidental or symptomatic coronary artery disease
• Uncontrolled atrial fibrillation (resting heart rate > 100/min)
• Pregnancy
• Unable to undergo CMR

Trial design

90 participants in 1 patient group

Arrhythmogenic mitral valve prolapse versus non-arrhythmogenic mitral valve prolapse

Description:

Surgical repair or replacement of the mitral valve due to significant mitral regurgitation according to standard of care.

Treatment:

Procedure: Mitral valve surgery