ARTEMIS-101: A Study of HS-20093 Combinations in Patients With Advanced Solid Tumors

Hansoh Pharma

Status and phase: Enrolling; Phase 1

Conditions: Advanced Solid Tumor

Treatments: Drug: Cetuximab; Drug: Cisplatin/ Carboplatin; Drug: Enzalutamide; Drug: HS-20093; Drug: Adebrelimab

Study type: Interventional

Funder types: Industry

Identifiers

NCT06332170

HS-20093-103

Details and patient eligibility

About

HS-20093 is a fully humanized IgG1 antibody-drug conjugate (ADC) which specifically binds to B7-H3, a target wildly expressed on solid tumor cells. The objectives of this study are to investigate the safety, tolerability, pharmacokinetics and anti-tumor activity of HS-20093 in combination with other anti-cancer agents in patients with advanced solid tumor patients.

Full description

This is a phase 1, open-label, multi-center, dose-escalation and expansion, phase 1 study in Chinses subjects with advanced solid tumors. This study is in design allowing assessment of safety, tolerability, pharmacokinetics and anti-tumor activity of HS-20093 in combination with other anti-cancer agents.

A total of 5 combination-treatments will be carried out in 3 cohorts. The target population of dose escalation part is patients have progressed on or intolerant to available standard therapies, and the dose expansion part will enroll patients who have not received prior treatment for advanced/metastatic disease.

All patients will be carefully followed for adverse events during the study treatment and for 90 days after the last dose of study drug. Subjects will be permitted to continue therapy with assessments for progression if the product is well tolerated and sustained clinical benefit exists.

Enrollment: 610 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• At least age of 18 years at screening;

• Histologically or cytologically confirmed, locally advanced or metastatic solid tumors

  1. Dose escalation part will enroll advanced solid tumor for which standard treatment has proven ineffective or unavailable or intolerable.
  2. Dose expansion part will enroll patients who have not received prior treatment for advanced/metastatic disease.

• least one extra-cranial measurable lesion according to RECIST 1

• Agree to provide fresh or archival tumor tissue

• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0~1

• Life expectancy >= 12 weeks

• Agree to use medically accepted methods of contraception

• Men or women should be using adequate contraceptive measures throughout the study;

• Females subjects must not be pregnant at screening or have evidence of non-childbearing potential

• Signed and dated Informed Consent Form

Exclusion criteria

• Any of the following would exclude the subject from participation in the study:

treatment with any of the following: Previous or current treatment with B7-H3 targeted therapy Intolerable for any PD-L1 inhibitor, cetuximab, enzalutamide and cisplatin/ carboplatin Cytotoxic chemotherapy, investigational agents and anticancer drugs within 14 days prior to the first scheduled dose of HS-20093 Prior treatment with a monoclonal antibody within 28 days prior to the first scheduled dose of HS-20093 Radiotherapy with a limited field of radiation for palliation within 2 weeks, or patients received more than 30% of the bone marrow irradiation, or large-scale radiotherapy within 4 weeks prior to the first scheduled dose of HS-20093 Major surgery within 4 weeks prior to the first scheduled dose of HS-20093

• Subjects with previous or concurrent malignancies
• Inadequate bone marrow reserve or organ dysfunction
• Evidence of cardiovascular risk
• Evidence of current severe or uncontrolled systemic diseases
• Evidence of mucosal or internal bleeding within 1 month prior to the first scheduled dose of HS-20093
• Known active infection requiring antibodies treatment within 2 weeks, or severe infection within 4 weeks prior to the first scheduled dose of HS-20093
• Subjects with current infectious diseases
• History of neuropathy or mental disorders
• Pregnant or lactating female
• History of severe hypersensitivity reaction, severe infusion reaction or idiosyncrasy to drugs chemically related to HS-20093 or any of the components of HS-20093
• Unlikely to comply with study procedures, restrictions, and requirements in the opinion of the investigator
• Any disease or condition that, in the opinion of the investigator, would compromise subject safety or interfere with study assessments

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: None (Open label)

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610 participants in 5 patient groups

Cohort 1a

Experimental group

Description:

HS-20093 and Adebrelimab

Treatment:

Drug: Adebrelimab

Drug: HS-20093

Cohort 1b

Experimental group

Description:

HS-20093, Adebrelimab and Cisplatin/ Carboplatin

Treatment:

Drug: Adebrelimab

Drug: HS-20093

Drug: Cisplatin/ Carboplatin

Cohort 2a

Experimental group

Description:

HS-20093 and Cetuximab

Treatment:

Drug: HS-20093

Drug: Cetuximab

Cohort 2b

Experimental group

Description:

HS-20093, Cetuximab and Cisplatin/ Carboplatin

Treatment:

Drug: HS-20093

Drug: Cisplatin/ Carboplatin

Drug: Cetuximab

Cohort 3a

Experimental group

Description:

HS-20093 and Enzalutamide

Treatment:

Drug: Enzalutamide

Drug: HS-20093