ARTEMIS Synovial Markers in Arthritis Childhood

University Hospital Center (CHU)

Status

Completed

Conditions

Septic Arthritis

Juvenile Idiopathic Arthritis

Treatments

Procedure: Articular punction, salivary samples, blood sample

Study type

Interventional

Funder types

Other

Identifiers

NCT02505828

2014-A01561-46 (Registry Identifier)

93612

Details and patient eligibility

About

The aim of this study is to find markers that could differentiate infectious and inflammatory arthritis. The investigators want to find markers by differential analysis by compare synovial fluids of septic and inflammatory arthritis. The investigators will use for this analysis, proteomics, cytokine dosage and monocyte typing by flow cytometry analysis. The investigators will use one marker or a score with biological and clinical data to discriminate arthritis of infectious and inflammatory etiology.

Enrollment

30 patients

Sex

All

Ages

6 months to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Septic arthritis with bacteriological identification
Juvenile idiopathic arthritis beyond the ILAR definition
Having acute arthritis requiring an articular draining
Child benefiting from a national insurance scheme
Collection of the consent of the parents or the legal representative

Exclusion criteria

Contraindication in an articular draining: platelet 50 000 / mm3, Rate of prothrombins lower than 70 %, activated partial thromboplastin times (APTT)> 1,5
Treatment by biotherapy, corticoids or other immuno suppressor in the month preceding the articular draining.
Treatment by antibiotic begun more than 24 hours before the draining.