Arterial and End-Tidal CO2 Gradient as a Mortality Predictor in Critical Care Patients

Gaziosmanpasa Research and Education Hospital

Status: Completed

Conditions: Pulmonary Embolism; Shock; Ventilation Perfusion Mismatch; Trauma; Critical Illness; Copd

Treatments: Diagnostic Test: EtCO2; Diagnostic Test: PaCO2

Study type: Interventional

Funder types: Other

Identifiers

NCT05341258

3751

Details and patient eligibility

About

Scoring systems (SOFA, APACHE-II etc.) are used to estimate the mortality rates of patients treated in the intensive care unit. . In the scoring systems used, the disfunction level of the organs of the patients is measured. Blood gas analysis is routinely performed in patients whom intubated in the intensive care unit and receiving mechanical ventilation support, and the patient's treatment is optimized according to the results of the examination. The patient's mechanical ventilation settings are regulated by analyzing the Partial Arterial Carbondioxide (paCO2) value in the patient's blood gas result. The difference between the paCO2 value in the blood gas and the End-tidal Carbondioxide (EtCO2) value measured in the mechanical ventilator is 3-5mmHg in normal healthy people, while this difference is seen more in critical care patients. In critically ill patients in the intensive care unit, there is a greater increase in the difference between paCO2 and ETCO2 in cases where mortality is high, such as global perfusion disorder, shock situations, and massive pulmonary embolism, etc. In this study, it was planned to investigate the use of the difference between the paCO2 value in the blood gas taken from the patient and the ETCO2 value measured in the mechanical ventilator to predict the mortality rate of the patient.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Critical Care Patients intubated in last 24 hours.

Exclusion criteria

• Patients younger than 18 years old.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

50 participants in 1 patient group

Critical Care Patients whom intubated last 24 hours

Other group

Description:

Critical Care Patients whom intubated last 24 hours

Treatment:

Diagnostic Test: PaCO2

Diagnostic Test: EtCO2