Arterial Calcifications in Nocturnal Hemodialysis and Renal Transplantation Versus Conventional Dialysis (NOCTX)

Dianet Dialysis Centers

Status: Completed

Conditions: Kidney Disease

Study type: Observational

Funder types: Other

Identifiers

NCT00950573

NOCTX

Details and patient eligibility

About

Objective:

1. To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;
2. To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

Full description

To assess whether nocturnal hemodialysis and renal transplantation are associated with less progression of coronary arterial calcification, compared with conventional hemodialysis and peritoneal dialysis; To identify the risk factors for coronary arterial calcification in dialysis and transplant patients, and to assess a possible interaction with treatment modality.

Enrollment: 184 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ESRD
• current age > 18 and < 75 yr
• ability to understand the study procedures
• willingness to provide written informed consent

Exclusion criteria

• life expectancy < 3 months
• claustrophobia
• allergy to iodinated contrast
• treatment incompliance, i.e. non-adherence to dialysis regimens and drug use
• GFR < 30 ml/min (according to MDRD formula) in renal transplant patients
• pregnancy

Trial design

184 participants in 4 patient groups

hemodialysis

Description:

patients treated with conventional hemodialysis

peritoneal dialysis

Description:

patients treated with peritoneal dialysis

nocturnal hemodialysis

Description:

patients treated with frequent nocturnal hemodialysis

kidney transplantation

Description:

patients treated with renal transplantation