Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Hypercalcemia; Kidney Disease

Treatments: Procedure: high calcium dialysate

Study type: Interventional

Funder types: Other

Identifiers

NCT00485706

ML4181

S50455

Details and patient eligibility

About

Renal patients have an increased risk for cardiovascular complications. There is also increased vascular calcification and bone metabolism is similarly abnormal in patients with chronic kidney disease.

In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering capacity in dialysis patients can be a mechanism for vascular calcifications.

Full description

Study hypothesis.

Patient with a higher ∆ Calcium (Calcium post - Calcium pre) have a diminished bone buffering capacity indicative for adynamic bone disease compared with patients with smaller ∆ Calcium.

This may result in higher extraosseous calcification and higher pulse wave velocity

∆ PTH/∆ Calcium may reflect the sensitivity and density of the calcium receptors; this may reflect parathyroid "health"

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• maintenance hemodialysis patients

Exclusion criteria

• dialysis <3 months
• aortobifemoral graft
• calcium level predialysis >10.5 mg/dl

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)