Arteriovenous Fistula Tissue Bank for Pre- and Post-Fistula Placement Specimens

University of Nebraska

Status: Completed

Conditions: Kidney Failure, Chronic

Treatments: Other: Biologic specimens

Study type: Observational

Funder types: Other

Identifiers

NCT00836862

0482-08-EP

Details and patient eligibility

About

This project will bank sera, DNA and vascular specimens from patients undergoing arteriovenous fistula creation and revision.

Full description

Hemodialysis patients utilizing an arteriovenous fistula (AVF) for hemodialysis access are 10 times less likely to develop bacteremia than those patients utilizing a hemodialysis catheter. Because of this, a great focus has been on placing AVF in all patients undergoing hemodialysis. While AVF are relatively simple to place from a surgical standpoint, 30-60% of AVF will not mature adequately to be used for hemodialysis. In order to be utilized for hemodialysis, the blood flow in the vein used to create the AVF will need to increase by over 100 fold. In order to do so, the vein will need to dilate by more than 150%. AVF which fail to mature do not dilate, and the major histologic finding in these AVF has been neointimal hyperplasia. The factors (both circulating and tissue) which contribute to AVF maturation or failure are poorly understood, and investigations in this area are limited. Current studies in the literature have either described pre-AVF vein characteristics, or have looked at serum or tissue specimens following AVF failure. To date, no studies have looked at specimens from patients both before and after fistula placement, or described factors associated with fistula maturation. This project will bank sera, DNA and vascular specimens from patients undergoing arteriovenous fistula creation and revision.

Enrollment: 43 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 19 years of age or greater
• Arteriovenous fistula placement for hemodialysis access scheduled within 30 days

Exclusion criteria

• Incompetent to provide informed consent

Trial design

43 participants in 1 patient group

Arteriovenous Fistula

Description:

A tissue bank will be created to collect serum, whole blood, and vein specimens obtained from participants undergoing Arteriovenous Fistula (AVF) placement and revision. The planned specimen harvests will allow for both pre- and post-AVF placement specimens from both maturing and failing AVF.

Treatment:

Other: Biologic specimens