Arteriovenous Plasma Multiomics in Patients With Disorders of Consciousness

Zhejiang University

Status: Completed

Conditions: Transient Ischemic Attack; Disorders of Consciousness

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT06403176

plasma multiomics

Details and patient eligibility

About

In order to determine the abnormal cerebral metabolism in the pathological state, we compared the blood of internal jugular vein, superior vena cava and radial artery during central venous catheterization. Metabonomics, proteomics and inflammatory factor microarray were used to detect the material differences in arteriovenous blood of patients with disorders of consciousness. At the same time, we concurrently compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

Full description

Background:It is unclear what substances the brain needs to ingest for its activity under pathological conditions

Method:The uptake and release of substances by the brain were observed by comparing arterial blood with internal jugular vein blood;The characteristics of brain metabolites were observed by comparing internal jugular vein blood with superior vena cava blood. Compared it with the peripheral plasma metabolome of two additional patient cohorts: those in-stent restenosis and non-restenosis.

Objective:By analyzing different substances, this paper briefly describes the pathological mechanism of patients with disorders of consciousness, and looks for potential prognostic biomarkers.

Enrollment: 100 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1.Patients with consciousness disorder caused by various severe brain injuries

Exclusion criteria

1. Patients who have been judged brain dead
2. There are persistent epileptic activity, inhibition or seizure inhibition patterns
3. Recent fever, abnormal liver and kidney function
4. Previous history of neurological or mental illness
5. Have a history of tumor
6. Inflammatory bowel diseases, hyperlipidemia, gastritis

Trial design

100 participants in 4 patient groups

Minimally conscious state (MCS)

Description:

Minimally conscious state (MCS): have reproducible signs of awareness and exhibit fluctuations in consciousness

Treatment:

Other: No intervention

Vegetative state (VS)

Description:

Vegetative state (VS): can open their eyes and preserve sleep-wake cycles, but unaware of themselves and their surroundings

Treatment:

Other: No intervention

Patients with In-Stent Restenosis

Description:

In-Stent Restenosis was defined as greater than 50% within or immediately adjacent (within 5 mm) to the stent implanted that was detected by digital subtraction angiography (DSA).

Treatment:

Other: No intervention

Patients with Non-Restenosis

Description:

In-Stent Restenosis was defined as less than 50% within or immediately adjacent (within 5 mm) to the stent implanted that was detected by digital subtraction angiography (DSA).

Treatment:

Other: No intervention