Arthroscopic Anterior Cruciate Ligament Reconstruction by Hamstring Graft With and Without Platelet-Rich Plasma

Muhammad Aamir Latif

Status: Completed

Conditions: Anterior Cruciate Ligament Injury

Treatments: Procedure: ACL reconstruction by hamstring graft; Procedure: ACL reconstruction by hamstring graft with PRP

Study type: Interventional

Funder types: Other

Identifiers

NCT07269522

DR-NAVEED-LGH

Details and patient eligibility

About

No local data exists regarding the outcomes of anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma. This study aimed to compare the functional outcomes of arthroscopic anterior cruciate ligament reconstruction by hamstring graft with and without platelet-rich plasma.

Full description

In animal studies, platelet-rich plasma has shown excellent results in accelerating the healing of the anterior cruciate ligament, but studies on human have shown varying clinical outcomes when investigating platelet-rich plasma for its effects on anterior cruciate ligament reconstruction. The findings of this study could provide important insights about the possible role of platelet-rich plasma in arthroscopic anterior cruciate ligament reconstruction by hamstring graft. to enhance early graft healing and reduce early complications, though its long-term effectiveness remains inconsistent. Studies suggest PRP may improve short-to-medium term outcomes like reduced pain and enhanced knee function,

Enrollment: 60 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any gender
• Aged 18-40 years
• With clinically and radiologically confirmed arthroscopic evidence of ACL injury

Exclusion criteria

• With comprised bilateral ACL tears
• Lack of fitness due to associated comorbidity
• Fractures of lower limb bones and/or spine/neurovascular injuries
• Injuries to other knee ligaments
• Significant knee joint arthritis
• Local skin infections

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

ACL reconstruction by hamstring graft with PRP group

Experimental group

Description:

Patients underwent anterior cruciate ligament reconstruction by hamstring graft along with platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

Treatment:

Procedure: ACL reconstruction by hamstring graft with PRP

ACL reconstruction by hamstring graft group

Experimental group

Description:

Patients underwent anterior cruciate ligament reconstruction by hamstring graft without platelet-rich plasma augmentation applying the standard arthroscopic ACL reconstruction technique.

Treatment:

Procedure: ACL reconstruction by hamstring graft