Articular Sonography: Healthy Subjects Versus Rheumatoid Arthritis Patients

Federal University of São Paulo

Status: Completed

Conditions: Disorders of Synovium, Multiple Sites; Disorders of Subchondral Bone, Multiple Sites; Disorders of Cartilage, Hand Joints; Healthy People; Arthritis, Rheumatoid

Study type: Observational

Funder types: Other

Identifiers

NCT01476865

1295/09

Details and patient eligibility

About

The purpose of this study is to establish the normality of sonographic synovial measures in joints more affected in rheumatoid arthritis patients and establish, in those joints, a sonographic value of synovium predictive of rheumatoid arthritis.

Full description

Rheumatoid arthritis (RA) is a chronic inflammatory, systemic and auto-imune disorder affecting primarily the joints. In RA, inflammatory synovium causes destruction of cartilage, erosion of the adjacent bone and ultimately loss of function of the affected joint. Newer imaging techniques, such as ultrasound (US), have shown promise in evaluation of RA. Many US scoring system have been used to classify and quantify the synovium, effusion, erosion and cartilage for assessing and monitoring AR. However, its use is considered problematical because there are very few data on normal joints and, at this point, there is no clear definition of excess amount of synovium in normal people.

Enrollment: 190 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• no articular disease (healthy group)
• establish rheumatoid arthritis (RA group)

Exclusion criteria

• diabetes
• hypothyroidism- hemophilia
• pregnancy
• previous septic arthritis
• previous articular surgery
• symptomatic osteoarthritis
• no superimposed collagenoses (RA group)

Trial design

190 participants in 2 patient groups

Healthy

Description:

normal, healthy people

RA

Description:

rheumatoid arthritis patients