Artificial Intelligence to Assess the Association Between Facial Characteristics and Coronary Artery Diseases

National Center for Cardiovascular Diseases

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03731936

20181104-2017-907

Details and patient eligibility

About

The purposes of this study are 1) to explore the association between facial characteristics and the increased risk of coronary artery diseases; 2) to evaluate the diagnostic efficacy of appearance factors for coronary artery diseases.

Full description

Several age-related appearance factors were described associated with increased risk of coronary artery diseases (CAD). However, several limitations made these facial risk factors hard to be utilized in clinical practice, including 1) low prevalence in CAD patients, 2) lack of specific definition, 3) poor reproducibility in artificial recognition.

Thus, the investigators designed a multi-center, cross-sectional study to explore the association between facial characteristics and CAD and evaluate the diagnostic efficacy of appearance factors for CAD. The investigators will recruit patients undergoing coronary angiography or coronary computer tomography angiography. Patients' baseline information and facial images will be collected. First, the investigators will explore the facial factors associated with CAD by using artificial intelligence technology to compare facial photographs between patients with CAD and without CAD. Secondary, the investigators will evaluate the dose-response relationship between facial characteristics and CAD. Third, the investigators will establish a CAD risk model based on facial factors, and evaluate the diagnostic effect of the model.

Enrollment: 6,864 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Undergoing coronary angiography or coronary computer tomography angiography
• Written informed consent

Exclusion criteria

• Prior percutaneous coronary intervention (PCI)
• Prior coronary artery bypass graft (CABG)
• Screening coronary artery disease before treating other heart diseases
• Without blood biochemistry outcome
• With artificially facial alteration (i.e. cosmetic surgery, facial trauma or make-up)
• Other situations which make patients fail to be photographed

Trial design

6,864 participants in 1 patient group

Model establishment and test group

Description:

Patients undergoing coronary angiography or coronary computer tomography angiography will be enrolled. Patients data will be used to establish the facial based diagnostic model of coronary artery diseases, and to prospectively validate the diagnostic effectiveness of the model.

Treatment:

Other: No intervention