Artificial Oocyte Activation Comparing Tow Different Agents

Ibn Sina Hospital

Status: Completed

Conditions: Oocyte Fertilization

Treatments: Drug: Strontium Chloride; Other: Artificial Oocyte activation; Drug: Ca Ionophore

Study type: Interventional

Funder types: Other

Identifiers

NCT02424214

IbnSina Oocyte activation

Details and patient eligibility

About

Comparing the efficacy of tow factors for artificial Oocyte Activation for poor quality Oocytes and Teratozoospermia patients.

Full description

The IVF outcome had been varied widely with a good portion of total fertilization failure even after the most advanced procedure for this group of patient Intracytoplasmic Sperm Injection, many factors that had been tested for assisting the failed group of patient to be fertilized artificially like Ca Ionophore, Strontium Chloride and others but we decide to compare the clinically proven factors for the efficacy and safety in a well randomized clinical trial and monitor the embryogenesis and pregnancy within the 2 groups.

Enrollment: 450 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• previous fertilization failure
• poor quality Oocytes
• poor sperms

Exclusion criteria

• normal patients

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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450 participants in 3 patient groups

Ca Ionophore group

Experimental group

Description:

Artificial Oocyte activation with Ca Ionophore for 20 min after Intracytoplasmic Sperm Injection

Treatment:

Drug: Ca Ionophore

Other: Artificial Oocyte activation

Strontium Chloride group

Experimental group

Description:

Artificial Oocyte activation with Strontium Chloride for 60 min after Intracytoplasmic Sperm Injection

Treatment:

Drug: Strontium Chloride

Other: Artificial Oocyte activation

Only Intracytoplasmic Sperm Injection

No Intervention group

Description:

after Intracytoplasmic Sperm Injection Oocytes will cultured and incubated