Artificial Shrinkage of Fresh Blastocysts (BlastoCollapse)
Status
Conditions
Treatments
Details and patient eligibility
About
The aim of the study is to determine if collapsing an embryo (or making it fold compactly by taking away its fluid) before the transfer in the uterine cavity improves pregnancy rates in assisted reproductive technology (ART).
Women coming to our ART center will be randomized in two groups : the collapsing group and a control group.
Pregnancy rates will be compared in the two groups. A biomarker (cell free DNA) will also be determined in each group and correlated to pregnancy occurrence.
Full description
This is a prospective randomized study designed to determine if artificial shrinkage (AS) before transfer of embryos impact clinical pregnancy rate in single blastocyst embryo transfer (SBET) cycle. Women elected for SBET will be randomized on transfer day in two arms:the AS group where blastocoelic cavity is artificially reduced by a laser pulse prior to transfer and a control group.
Clinical pregnancy rates will be compared. Secondarily, rate of monozygotic twin pregnancy and cell free DNA concentration in culture medium will be evaluated in the two groups.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Couple eligible for a transfer of a single embryo at the blastocyst stage
- Available couple for a follow up of 12 months
Exclusion criteria
- Attempt with frozen embryo or frozen oocyte
- Attempt with a pre-implantation diagnosis
- Patient has not signed informed consent
- Couple in a period of exclusion determined by a previous study
- Couple under legal protection, guardianship or guardianship
Trial design
Primary purpose
Allocation
Interventional model
Masking
150 participants in 2 patient groups
Trial contacts and locations
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal