Aschistosoma Haematobiumspecific microRNAas a Tumor Marker for Early Diagnosis and Prognosis of Bilharzial Bladder Cancer in Eygpt

Sohag University

Status: Not yet enrolling

Conditions: Bladder Cancer

Treatments: Diagnostic Test: urinary micro RNA detection

Study type: Interventional

Funder types: Other

Identifiers

NCT05697224

soh-med-22-11-12

Details and patient eligibility

About

miRNAs have been detected in different bodily fluids, which suggests significant potential, such as their use as biomarkers in diagnostics and prognostics. Sha-mir-71a was abundantly found in the urine of patients with bladder cancer as compared to benign bladder cystitis associated with schistosomiasis . Additionally, this miRNA was more highly detected in urine samples from patients with bilharzial bladder cancer than bladder cancer not associated with bilharziasis (schistosomiasis), suggesting its specificity in the identification of bladder cancer associated with infection.

Enrollment: 50 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• urinary symptoms (hematuria, urinary retention, dysuria... etc.), who were planned to undergo cystoscopy for suspicion of bladder cancer (BC) or benign bilharzial cystitis (Bil), will be selected.

Exclusion criteria

• : In bladder cancer group Patients who have received chemotherapy, or with previously diagnosed other malignancy within the past 5 years.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

chronicurinary schistosomiasis

Active Comparator group

Treatment:

Diagnostic Test: urinary micro RNA detection

bladder cancer diseased patients

Active Comparator group

Treatment:

Diagnostic Test: urinary micro RNA detection