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Ascitic Fluid Microbiome in Liver Cirrhosis

M

Medical University of Graz

Status

Withdrawn

Conditions

Polymerase Chain Reaction
Ascitic Fluid, Microbiota
Sequence Analysis
Microbiota

Treatments

Other: Stool samples
Other: Skin swaps from puncture side
Other: Ascitic fluid puncture

Study type

Observational

Funder types

Other

Identifiers

NCT02813590
25-326 ex 12/13

Details and patient eligibility

About

Ascitic fluid microbiome is going to be investigated in this study by using internal transcripted spacer (ITS) and 16S ribosomal RNA (rRNA) polymerase chain reaction (PCR) and sequencing as conventional culture methods are lacking sensitivity regarding diagnosis of spontaneous bacterial peritonitis (SBP).

All patients with routinely performed ascitic fluid puncture and underlying liver cirrhosis are included in this study. Next generation sequencing (NGS) in ascitic fluid, skin swaps from puncture side and stool samples as well as conventional culture methods are performed to investigate the difference in the microbiome between patients with and without SBP.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Underlying decompensated liver cirrhosis
  • routinely performed ascitic fluid puncture
  • informed consent

Exclusion criteria

Trial design

0 participants in 2 patient groups

Patients with liver cirrhosis and with SBP
Treatment:
Other: Stool samples
Other: Skin swaps from puncture side
Other: Ascitic fluid puncture
Patients with liver cirrhosis and without SBP
Treatment:
Other: Stool samples
Other: Skin swaps from puncture side
Other: Ascitic fluid puncture

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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