Aseptic Meningoencephalitis in Slovenia

University Medical Centre Ljubljana

Status: Unknown

Conditions: Aseptic Meningitis

Treatments: Drug: symptomatic therapy; Drug: Ceftriaxone or Doxycycline; Other: questionnaire; Drug: Acyclovir

Study type: Observational

Funder types: Other

Identifiers

NCT02328469

mgt-0614

Details and patient eligibility

About

The main objective of this study is:

• to establish etiology of acute aseptic meningitis/meningoencephalitis in Slovenia
• to assess the clinical course and outcome of tick-borne encephalitis and Lyme neuroborreliosis
• to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with tick-borne encephalitis and Lyme neuroborreliosis

Enrollment: 800 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• clinical picture compatible with aseptic meningitis/meningoencephalitis
• age 18 years or older
• clear cerebrospinal fluid on macroscopic examination
• cerebrospinal pleocytosis (> 5 x 106 white blood cells per liter)

Exclusion criteria

• younger than 18 years
• pregnant women

Trial design

800 participants in 5 patient groups

unidentified aseptic meningitis

Description:

Patients with etiologically unidentified aseptic meningitis will be treated with symptomatic therapy and will be asked to complete a questionnaire.

Treatment:

Drug: symptomatic therapy

Other: questionnaire

tick-borne encephalitis

Description:

Patient with aseptic meningitis in whom serological diagnosis of tick-borne encephalitis will be established. Patients will be treated with symptomatic therapy and will be asked to complete a questionnaire.

Treatment:

Drug: symptomatic therapy

Other: questionnaire

Lyme neuroborreliosis

Description:

Patients with acute aseptic meningitis in whom Lyme neuroborreliosis will be proven or suspected according to microbiological criteria. Patients will be treated with antibiotic therapy (ceftriaxone or doxycycline) and will be asked to complete a questionnaire.

Treatment:

Drug: symptomatic therapy

Other: questionnaire

Drug: Ceftriaxone or Doxycycline

healthy controls

Description:

Patients will be asked to refer a spouse to serve as a control . If unmarried they will be asked to refer a family member or a friend of +/- 5 years to serve as a control.

Treatment:

Drug: symptomatic therapy

Other: questionnaire

identified aseptic meningitis

Description:

Patients with microbiologically identified cause of acute aseptic meningitis/meningoencephalitis will receive symptomatic therapy. If the identified causative agent will be Herpes Simplex Virus or Varicella Zoster Virus, patients will be treated with acyclovir and will be asked to complete a questionnaire.

Treatment:

Drug: symptomatic therapy

Other: questionnaire

Drug: Acyclovir