Aspergillus and Chronic Obstructive Pulmonary Disease Evolution (AspergBPCO)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Diagnostic Test: Questionnaries

Study type: Interventional

Funder types: Other

Identifiers

NCT03646851

PI2017_843_0024

Details and patient eligibility

About

This is a prospective multicenter cohort study which includes all consecutive COPD patients who come for a visit in one the participating pneumologist. They will have to do a sputum and to complete some questionnaries. Questionnaries will be redone by phone after 1 and 3 months and during the visit after 6 months. We will correlate aspergillus presence in sputum with quality of life (QoL), and COPD symptoms evaluated by questionnaires.

Full description

Aspergillosis disease is a growing problem. These diseases are not yet uncommon in chronic obstructive pulmonary disease patients. (COPD).

Aspergillosis disease are very difficult to be diagnosed or treated. Isolation of aspergillus in sputum of patients is not always responsible of a real disease. Need of treatment is discussed. That is why, we will conduct a prospective cohort study to evaluate aspergillus rate in respiratory samples of COPD patients (GOLD stage III or IV)

Enrollment: 100 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD patients GOLD stage III and IV

Exclusion criteria

• Cystic fibrosis
• Pulmonary fibrosis
• hematological malignancy
• known aspergilloma
• allergic bronchopulmonary aspergillosis

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

COPD

Experimental group

Description:

COPD patients GOLD stage III and IV

Treatment:

Diagnostic Test: Questionnaries