Aspirin Resistance Following Coronary Bypass Surgery

Sheba Medical Center

Status: Terminated

Conditions: Ischemic Heart Disease

Treatments: Procedure: Coronary artery bypass surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT00260377

SHEBA-03-3107-JL-CTIL

Details and patient eligibility

About

Aspirin was proved to be the drug preventing vein grafts from closure and improving clinical outcome after coronary artery bypass surgery. It appears to be effective when being prescribed as early as first 48 hr. after the operation without increasing the incidence of bleeding complications. the exact effective dose is not known.

Sex: All

Ages: 30 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing Coronary artery bypass surgery
• Patients who signed Informed Consent Form

Exclusion criteria

• Concomitant valve surgery or carotid surgery or off-pump surgery
• Need for anticoagulation therapy for any reason
• Another antiplatelet medications at least 7 days prior to surgery
• Contra-indication for aspirin treatment
• Thrombocytopenia / thrombocytopathia
• NSAIDs treatment for chronic medical conditions
• Reluctance to participate in the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)