Assesment of Salivary Alpha-amylase Levels Before and After Ovulation

Saglik Bilimleri Universitesi Gulhane Tip Fakultesi

Status: Unknown

Conditions: Salivary Amylase

Treatments: Other: Salivary alpha-Amylases

Study type: Observational

Funder types: Other

Identifiers

NCT02664480

Gulhane School of Medicine

Details and patient eligibility

About

Investigators aimed to investigate whether there is an association between ovulation and salivatory alpha amylase (sAA) activity in menstrual cycles during a month period in a group of reproductive women.

Full description

Saliva is a readily available specimen, which can be collected by noninvasive procedures and contains many hormones, drugs and antibodies of interest in screening and diagnosis. With a salivary specimen, one can collect multiple specimens at the optimum times for diagnostic information. Saliva can be collected in remote sites by unskilled personnel and, is stable at ambient temperatures for several weeks. Because of diurnal and monthly variations, several steroid hormones need multiple samples collected early in the morning or late at night or at the same time every day for a month to give meaningful results. Such collections are often very expensive, inconvenient or impossible to do with blood.

Investigators aimed to investigate whether there is an association between ovulation and salivatory alpha amylase (sAA) activity in menstrual cycles during a month period in a group of reproductive women.

Enrollment: 100 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of PCOS (study group)
• Reproductive age regular menses women

Exclusion criteria

• pregnancy,
• breastfeeding,
• known liver disease,
• alcohol abuse,
• diabetes mellitus,
• smoking
• treatment with oral glucocorticoids
• treatment with hormonal contraceptives.

Trial design

100 participants in 2 patient groups

study group

Description:

Reproductive age women with polycystic ovary syndrome and irregular menses (Salivary Alpha-amylase Levels of 3rd and 24th day of menstrual cyclus)

Treatment:

Other: Salivary alpha-Amylases

control group

Description:

Reproductive age women with regular menses (Salivary Alpha-amylase level of 3rd and 24th day of menstrual cyclus)

Treatment:

Other: Salivary alpha-Amylases