Assessing How Normal Variations in CT Scanning Affects Its Interpretation

Memorial Sloan Kettering Cancer Center (MSK)

Status: Active, not recruiting

Conditions: Colorectal Cancer Metastatic

Treatments: Diagnostic Test: CT scan

Study type: Observational

Funder types: Other; NETWORK

Identifiers

NCT03038568

17-010

Details and patient eligibility

About

The purpose of the study is to see how measurements of tumor differences vary with slight changes in CT scan parameters. Reproducible radiomic features can be extracted for abdominal tumors, and specifically colorectal liver metastases, imaged with clinical CT scanners even in the setting of variable scan parameters and variable contrast timing. Participants will be consented to undergo an additional CT of their abdomen.

Enrollment: 169 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients ≥ 18 years of age on the day of signed informed consent
• Patients scheduled and approved for contrast enhanced CT that includes imaging of the abdomen and pelvis following the Department of Radiology standard of care protocol as per local institutional guidelines
• Patients with measurable colorectal liver metastases on prior imaging, with at least one tumor greater than 2.0 cm in axial maximal diameter

Exclusion criteria

• Patient who is pregnant and/or lactating
• Patient scheduled for CT that includes the abdomen with a multiphasic contrast enhanced protocol (e.g. Triple Phase or Quadruple Phase Liver CT)
• Patient who require reduced intravenous contrast dose based on the Department of Radiology contrast policy as per local institutional guidelines
• Any other medical condition, including mental illness or substance abuse, deemed by the Investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or follow up procedures

Trial design

169 participants in 18 patient groups

Cohort 1

Description:

-15 second time gap between routine abdominal CT and add on CT, Noise Index of 12

Treatment:

Diagnostic Test: CT scan

Cohort 2

Description:

-15 second time gap between routine abdominal CT and add on CT, Noise Index of 14

Treatment:

Diagnostic Test: CT scan

Cohort 3

Description:

-15 second time gap between routine abdominal CT and add on CT, Noise Index of 16

Treatment:

Diagnostic Test: CT scan

Cohort 4

Description:

-10 second time gap between routine abdominal CT and add on CT, Noise index 12

Treatment:

Diagnostic Test: CT scan

Cohort 5

Description:

-10 second time gap between routine abdominal CT and add on CT, Noise index 14

Treatment:

Diagnostic Test: CT scan

Cohort 6

Description:

-10 second time gap between routine abdominal CT and add on CT, Noise index 16

Treatment:

Diagnostic Test: CT scan

Cohort 7

Description:

- 5 second time gap between routine abdominal CT and add on CT, Noise index 12

Treatment:

Diagnostic Test: CT scan

Cohort 8

Description:

- 5 second time gap between routine abdominal CT and add on CT, Noise index 14

Treatment:

Diagnostic Test: CT scan

Cohort 9

Description:

- 5 second time gap between routine abdominal CT and add on CT, Noise index 16

Treatment:

Diagnostic Test: CT scan

Cohort 10

Description:

+ 5 second time gap between routine abdominal CT and add on CT, Noise index 12

Treatment:

Diagnostic Test: CT scan

Cohort 11

Description:

+ 5 second time gap between routine abdominal CT and add on CT, Noise index 14

Treatment:

Diagnostic Test: CT scan

Cohort 12

Description:

+ 5 second time gap between routine abdominal CT and add on CT, Noise index 16

Treatment:

Diagnostic Test: CT scan

Cohort 13

Description:

+ 10 second time gap between routine abdominal CT and add on CT, Noise index 12

Treatment:

Diagnostic Test: CT scan

Cohort 14

Description:

+ 10 second time gap between routine abdominal CT and add on CT, Noise index 14

Treatment:

Diagnostic Test: CT scan

Cohort 15

Description:

+ 10 second time gap between routine abdominal CT and add on CT, Noise index 16

Treatment:

Diagnostic Test: CT scan

Cohort 16

Description:

+ 15 second time gap between routine abdominal CT and add on CT, Noise 12

Treatment:

Diagnostic Test: CT scan

Cohort 17

Description:

+ 15 second time gap between routine abdominal CT and add on CT, Noise 14

Treatment:

Diagnostic Test: CT scan

Cohort 18

Description:

+ 15 second time gap between routine abdominal CT and add on CT, Noise 16

Treatment:

Diagnostic Test: CT scan