Assessing The Effectiveness of a Preoperative High Intensity Interval Training Programme In Older Colorectal Cancer Patients (HITCa)

University of Nottingham

Status

Completed

Conditions

Preoperative Care

Colorectal Neoplasms

Aged

Exercise

Treatments

Behavioral: HIT

Study type

Interventional

Funder types

Other

Identifiers

NCT02188342

HITCa

Details and patient eligibility

About

The primary aim of this study is to determine whether an improvement in aerobic fitness, as judged by an increase in VO2peak, can be achieved within 31 days via HIT programme in a group of older, colorectal cancer patients.

Full description

12 high intensity interval training exercise sessions on a static cycle ergometer, over a period of 31 days. Each session lasts 18 minutes.

At the beginning and end of the study the following measures will be used to assess change in fitness, body composition and muscle metabolism. DXA scan, USS of thigh, VO2 peak cycling test, short performance battery tests, quality of life questionnaires and muscle biopsy.

Enrollment

18 patients

Sex

All

Ages

18 to 88 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Confirmed colorectal cancer
Offered curative treatment by the Royal Derby Hospital NHS Foundation Trust Colorectal Cancer Multidisciplinary Team
Male and female
18-88 years of age

Exclusion criteria

Uncontrolled hypertension (BP > 160/100),
Angina,
Heart failure (class III/IV),
Cardiac arrthymias,
Right to left cardiac shunt,
Recent cardiac event,
Previous stroke/TIA,
Aneurysm (large vessel or intracranial),
Severe respiratory disease including pulmonary hypertension,
COPD/asthma with an FEV1 less than 1.5 l,
Coagulation disorders,
Scarring disorders.
Current neoadjuvant chemo/radiotherapy
Inability to complete the consent process Involvement in invasive research study in previous 3 months.