Assessing the Effects of a Neurobehavioral Intervention on Symptoms of Obsessive Compulsive Disorder (CCT-OC)

Boston University Charles River Campus

Status: Completed

Conditions: Obsessive Compulsive Disorder

Treatments: Behavioral: Cognitive Control Training; Behavioral: Peripheral Vision Task

Study type: Interventional

Funder types: Other

Identifiers

NCT01414023

BU-2487

NCT01414023 (Registry Identifier)

Details and patient eligibility

About

This experiment will examine if the use of computerized tasks that train individuals to control their attention more effectively will predict individual differences in obsessive-compulsive symptoms, rumination and BDNF change. After giving consent, filling out self-report forms, and giving blood for the BDNF test, 80 participants will be randomized to Cognitive Control Training (CCT) or Peripheral Vision Task (PVT) (described below) which will be administered three times over a two week period. At the third visit, participants will also complete an anagram task and repeat the blood draw for BDNF testing. The investigators hypothesize that computerized tasks that train individuals to control their attention more effectively will reduce Obsessive Compulsive (OC) symptoms. Additionally, individuals training in CCT will show increased ability to disengage from unattainable goals as assessed by responses to an unsolvable anagram task. Finally, individuals training in CCT will show a greater increase in BDNF levels as compared to individuals training in PVT.

Enrollment: 48 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults ages 18-65 years
• OCI-R total score ≥ 16
• Ability to read and provide informed consent.
• Familiarity with a computer keyboard and mouse.

Exclusion criteria

• BDI-II suicidality score of > 1

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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48 participants in 2 patient groups, including a placebo group

CCT

Experimental group

Description:

Cognitive Control Training - Pace Auditory Serial Addition Task (PASAT;(Gronwall, 1977): A computer version of the PASAT will be used to measure sustained attention and working memory. Participants are asked to add serially presented numbers. Attention Control Intervention (Wells, 2000): This task involves training individuals to attend differentially to multiple auditory sources (e.g., by counting tones, discriminating the location of tones, and moving their attention between auditory sources for a prolonged period).

Treatment:

Behavioral: Cognitive Control Training

PVT

Placebo Comparator group

Description:

Peripheral Vision Task (PVT; C. Moore, personal communication): This task serves as a non-active control condition which does not target the brain regions influenced by the Wells and PASAT tasks. Participants focus on the placement of dots on a computer screen in this task while listening to a tone.

Treatment:

Behavioral: Peripheral Vision Task