Assessing the Effects of Photobiomodulation on Clinical Recovery From Concussion in Adolescents

The University of Texas System (UT)

Status

Enrolling

Conditions

Sports-related Concussion

Treatments

Device: Photobiomodulation therapy (PBMt)

Other: Standard of Care

Study type

Interventional

Funder types

Other

Identifiers

NCT06239818

HSC-MS-23-0871

Details and patient eligibility

About

The purpose of this study is to compare effects of Photobiomodulation therapy (PBMt) to standard of care in adolescent athletes at risk for delayed recovery from subacute sports concussion, to substantiate the impact of subacute PBMt over time on functional and structural connectivity of the brain using advanced MRI sequences and to correlate the psychological and behavioral outcomes to neuroimaging findings

Enrollment

30 estimated patients

Sex

All

Ages

13 to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

current participants in a school- or club-sponsored sport (contact or non-contact)
access to wireless internet service at home
diagnosis of sports-related concussion (SRC) (according to consensus diagnostic criteria) by a licensed healthcare provider,3-7 days from the concussive injury at the time of enrolment
considered at-risk for protracted recovery based on Immediate Post-concussion Assessment and Cognitive Testing (ImPACT) performance and symptom reporting on the Post-Concussion Symptom Scale (PCSS)

Exclusion criteria

acute neurologic deterioration to a Glasgow Coma Scale score less than 13
neurosurgical intervention
abnormal CT scan
concomitant extracranial injury worse than mild
pre-injury conditions which confound effects of SRC (e.g., epilepsy, schizophrenia, bipolar illness, mental deficiency, hospitalization for TBI)
substance dependence
inability to speak fluent English
Individuals who are taking benzodiazepines, anti-convulsants, mood stabilizers, stimulants, opioids, sleep aids, or other neuropsychiatric medications