Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging Technologies

University of California Irvine (UCI)

Status and phase: Completed; Early Phase 1

Conditions: Collagen Fibril Alteration

Treatments: Drug: Tretinoin cream 0.1%

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02410980

20141508

Details and patient eligibility

About

The researchers will assess the effects of treatment with tretinoin cream on human skin by using non-invasive optical imaging technologies.

Full description

The researchers will evaluate changes in the dermis and skin properties as the effect of treatment with Tretinoin cream (0.1%) by using the following optical imaging techniques.

1. Multiphoton microscopy using a clinical tomograph (MPTflex, Jenlab, Germany)
2. Multispectral Imaging using a device developed at Beckman Laser Institute, UC Irvine

Enrollment: 15 patients

Sex: Female

Ages: 45+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female 45 years of age or older - Skin type scale I to III

Exclusion criteria

• Large amount of dark, coarse hair on the arms
• History of allergies to alpha hydroxy acids (AHAs), retinoids, soaps, fragrances, sunscreens or Latex
• Currently using over-the-counter AHA or retinol within one month or prescription retinoid within three months of the start of the study.
• History of skin cancer, including squamous or basal cell carcinoma at the treatment site or history of malignant melanoma.
• History of diabetes
• Currently pregnant or nursing

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Tretinoin cream 0.1%

Experimental group

Description:

Assessment of the skin change

Treatment:

Drug: Tretinoin cream 0.1%