Assessing the Impact of High Theacrine Doses on Hemodynamic Measures

Titch Madzima

Status: Completed

Conditions: Cognitive Performance in Healthy Volunteers; Hemodynamic Measure

Treatments: Dietary Supplement: High dose theacrine; Dietary Supplement: Low dose theacrine; Dietary Supplement: Medium dose theacrine; Dietary Supplement: Maltodextrin (Placebo)

Study type: Interventional

Funder types: Other

Identifiers

NCT07376564

2791

Details and patient eligibility

About

This project measured physiological and cognitive variables to determine the effectiveness of Theacrine (TCR) as a stimulant at doses greater than those previously tested. The study will be the first TCR study to use doses relative to body weight and will investigate impacts on regular caffeine consumers. A secondary aim of the study is to determine the impact of acute TCR supplementation on salivary cortisol and sAA, two physiological measures of stress and sympathetic nervous system activation. The findings of the study will provide new insight into the effects of higher TCR dosages, contributing to the analysis of TCR as a caffeine alternative for individuals with hypertension, tachycardia, or healthy caffeine consumers wanting to avoid a stimulant with adverse or habitual effects

Enrollment: 19 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

- habitual caffeine consumer (≥2 days/week)

Exclusion criteria

• existing heart disease or conditions (cardiovascular and/or heart disease, stroke, diabetes hypertension, tachycardia)
• a smoker
• allergy to caffeine or Theacrine
• caffeine sensitivity (negative symptoms such as jitters after consuming low doses)
• pregnant
• on heart or blood pressure medication

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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19 participants in 4 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

6 mg/kg Maltodextrin Placebo

Treatment:

Dietary Supplement: Maltodextrin (Placebo)

Low dose

Experimental group

Description:

3mg/kg Theacrine

Treatment:

Dietary Supplement: Low dose theacrine

Medium dose

Experimental group

Description:

6mg/kg Theacrine

Treatment:

Dietary Supplement: Medium dose theacrine

High dose

Experimental group

Description:

9mg/kg Theacrine

Treatment:

Dietary Supplement: High dose theacrine