Assessing the Impact of Opioid-Free Anesthesia Using the Modified Mulimix Technique.

Zulekha Hospitals

Status: Completed

Conditions: Opioid Use

Treatments: Drug: opioid-FREE anesthesia.; Drug: opioid-CONTAINING anesthesia.

Study type: Observational

Funder types: Other

Identifiers

NCT06216210

T.G.H.45/275

Details and patient eligibility

About

The effective management of post-operative pain in the setting of bariatric surgery presents significant hurdles for both anesthesiologists and surgeons. The objective of this study was to assess the effects of opioid-free anesthesia (OFA) using the modified mulimix technique on the levels of plasma interleukin-2 (IL-2) and interleukin-6 (IL-6) as the primary outcome. Additionally, the study aimed to evaluate the duration of analgesia and the analgesic requirements within the first twenty-four hours after surgery.

Full description

Objectives: The effective management of post-operative pain in the setting of bariatric surgery presents significant hurdles for both anesthesiologists and surgeons. The objective of this study was to assess the effects of opioid-free anesthesia (OFA) using the modified mulimix technique on the levels of plasma interleukin-2 (IL-2) and interleukin-6 (IL-6) as the primary outcome. Additionally, the study aimed to evaluate the duration of analgesia and the analgesic requirements within the first twenty-four hours after surgery.

Methods: 60 patients were systematically selected and randomly assigned to Group A (OFA) and Group B (Opioid-Containing Anesthesia, OCA), with the modified Mulimix technique employed. Serum samples were collected from all patients, both at the onset of the skin incision and after the surgical procedure. These samples were then used to assess interleukin-2 (IL-2) and interleukin-6 (IL-6) levels. Additionally, the post-operative analgesic consumption was documented.

Enrollment: 60 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• both genders
• aged between 20 and 50 years
• patients fall under the American Society of Anesthesia (ASA) categories II-III
• body mass index (BMI) ranging from 35-50.

Exclusion criteria

• patients who declined participation in the trial
• pregnant women
• patients who encountered challenges in communication that could potentially impede a dependable postoperative evaluation

Trial design

60 participants in 2 patient groups

Group (A)

Description:

Opioid-free anesthesia group

Treatment:

Drug: opioid-FREE anesthesia.

Group (B)

Description:

Opioid-containing anesthesia group.

Treatment:

Drug: opioid-CONTAINING anesthesia.