Assessing the Quality of Breast Milk

U

USDA, Western Human Nutrition Research Center

Status

Completed

Conditions

Micronutrient Deficiency

Treatments

Dietary Supplement: Multiple micronutrient supplement (Nutri-Fem)

Study type

Interventional

Funder types

Other
Other U.S. Federal agency

Identifiers

NCT02756026
BMQ
429296-1 (Other Identifier)

Details and patient eligibility

About

The purpose of the study is to establish a protocol for collecting representative samples of breastmilk (BM) that can be used to assess the effect of maternal micronutrient (MN) supplementation on milk MN concentrations. The investigators will determine which breastfeeding episode during the 24 hour period best represents the maternal status; and within the episode whether fore, mid or hind milk samples be collected in future studies.

Full description

Mother-infant pairs were recruited in the peri urban area of Dhaka, Bangladesh to participate in a protocol development study at International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b). The participants will spend 5 days in a metabolic unit of icddr,b and the procedures are as follows: On day 1, mother-infant pairs will come to the facility, consume their evening meal and spend the night. On day 2, the mothers will be asked to breastfeed their infant from one breast for as long as the infant is interested. An electric breast pump will be placed simultaneously on the other breast for a Full Milk (FM) collection. For the duration of the study the same breast will be used for feeding the infant the other breast will be used for the FM collection. Three separate aliquots of fore milk (up to 1 minute), mid (50 mL), and hind (until the breast is empty) milk will be collected by a special funnel attached to the breast pump. A 5 mL aliquot of BM will be removed from each the 3 aliquots for creamatocrit measurement and later vitamin and mineral determinations. The remainder of the pumped breast milk will be pooled and given to the mother to feed to her infant. A fasting blood sample (7 mL) will be obtained by venipuncture to measure maternal MN status. A breakfast meal will be served to the mother after the first feeding and the blood draw. The mother will be asked to refrain from breastfeeding her infant for the next 2-3 hours then the collection procedure will be repeated until the mother goes to sleep at night, and at any time during the night that the mother wakes to feed her infant. The meals for breakfast, lunch and dinner will be low in micronutrients. On day 3, the mothers will be given one commercial multiple micronutrient supplement tablet containing the Recommended Dietary Intake (RDA). Milk collection procedures will be repeated the same as on day 2. The meals for breakfast, lunch and dinner will be low in micronutrients. Between breast milk collections the staff will collect maternal and infant anthropometry data, and administer Food Frequency (FF) and morbidity questionnaires. On day 4, the mothers will be given two commercial multiple micronutrient supplement tablets containing the Recommended Dietary Intake (RDA). Milk collection procedures will be repeated the same as on day 3. The meals for breakfast, lunch and dinner will be low in micronutrients. On day 5, the study will end with a final collection of BM in the morning and the study participants will be discharged from the facility.

Enrollment

19 patients

Sex

Female

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • BMI >18.5 Healthy
  • In the 2nd to 4th month of lactation and breastfeeding ≥12 times/d
  • Breast-feeding only one infant
  • Non-pregnant
  • Willing to spend 4 days and nights at the metabolic unit
  • Willing to perform the procedures of BM collection using the breast pump.

Exclusion criteria

  • Severe anemia (Hb <90 g/L) by HemoCue
  • Currently taking micronutrient supplements
  • Current pregnancy
  • Current illness
  • Current Mastitis

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

19 participants in 1 patient group

Micronutrient supplementation
Experimental group
Description:
On day 3, all mothers are given a commercial multiple micronutrient supplement (Nutri-Fem) manufactured by Thorne, containing the Recommended Dietary Intake (RDA). On day 4, all mothers are given two commercial multiple micronutrient supplements (Nutri-Fem) manufactured by Thorne, containing twice the Recommended Dietary Intake (RDA).
Treatment:
Dietary Supplement: Multiple micronutrient supplement (Nutri-Fem)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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