Assessing the Risk of CMV Infection of the Renal Transplant About R + by Cellular Immunity Analyzed by the QuantiFERON ®-CMV Test. (QUANTIC-R+)

University of Limoges (UL)

Status: Terminated

Conditions: Renal Transplant Recipient; Immunized Against the Cytomegalovirus

Treatments: Biological: CMV Infection

Study type: Observational

Funder types: Other

Identifiers

NCT02064699

I10002 QUANTIC-R+

Details and patient eligibility

About

Cytomegalovirus (CMV) infection was observed in over 30% of organ recipients with high morbidity. Moreover, no prophylaxis, 75% R + D-transplanted, 55%, R + D + and D-25% R + develop CMV. The number of available antiviral drugs is reduced and noticeable side effects (neutropenia, renal toxicity) lead to premature discontinuation of therapy or the use of reduced doses that promote non-response to treatment and the emergence of resistance. In case of neutropenia, there are more an increased risk of secondary rejection due to the reduction of immunosuppressive treatment rendered necessary by the haematological reached.

Rational use of these molecules is necessary with essential today as the optimal duration of prophylaxis primary issues and the prophylaxis of recurrences in case of CMV infection reported in.

Full description

QuantiFERON-CMV ® is a fast and standardized test that evaluates the CMV specific cellular immunity measuring the amount of secreted Interferon gamma (IFN gamma) in plasma by ELISA. It uses more epitopes of proteins including CMV glycoprotein B (gB), protein IE-1 and protein pp65 and protein pp50, which are specific for (human leukocyte antigen) HLA class I. Pretreatment of the sample is simple and plasma can be stored, frozen, for a delayed dose of interferon.

Enrollment: 75 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Renal transplant recipient
• Immunized against the Cytomegalovirus

Exclusion criteria

• Not willing to participate, no health insurance
• clinical evidence of active viral infection
• renal transplant recipient whose treatment includes induction antilymphocyte antibodies

Trial design

75 participants in 1 patient group

CMV infection

Description:

Renal transplant recipient immunized against the Cytomegalovirus

Treatment:

Biological: CMV Infection