Assessing the Stability of Transcranial Magnetic Stimulation Plasticity Responses

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University of Miami

Status

Completed

Conditions

Healthy

Treatments

Behavioral: Short-term aerobic exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT03034629
20161183

Details and patient eligibility

About

The overall goal of this proposed study is to assess the reliability of plasticity measured by transcranial magnetic stimulation (TMS) interleaved with intermittent theta-burst stimulation plasticity measures and to assess the influence of an acute bout of aerobic exercise on TMS plasticity measures.

Enrollment

16 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Adult males and females aged 18-70 years old.
  • Primary language is English
  • Exercise clearance

Exclusion criteria

  • Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures
  • History of migraines
  • History of fainting spells of unknown or undetermined etiology that might constitute seizures
  • History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistance epilepsy
  • Any current history of psychiatric illness
  • Any unstable medical condition
  • No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following:
  • The subject's past medical history, drug does, history of recent medication changes or duration of treatment, and combination with other central nervous system active drugs.
  • The published TMS guidelines review medications to considered with TMS (Rossi, Hallet, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009)
  • Any metal in the brain, skull or elsewhere unless approved by the responsible MD
  • Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
  • Intracranial lesion
  • Substance abuse or dependence within the past six months

Trial design

Primary purpose

Other

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

16 participants in 1 patient group

Short-term aerobic exercise
Experimental group
Description:
One bout of moderate intensity exercise (75% of maximal predicated heart rate).
Treatment:
Behavioral: Short-term aerobic exercise

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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