Assessment of Antithrombin III, Protein C, Protein S and D-dimer in Acute Leukemia

Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy

Status: Completed

Conditions: Acute Leukemia

Treatments: Diagnostic Test: Protein S; Diagnostic Test: D-dimer; Diagnostic Test: Flow cytometry immunophenotyping; Diagnostic Test: Protein C; Diagnostic Test: Antithrombin III

Study type: Observational

Funder types: Other

Identifiers

NCT07036809

clinicalpath1

Details and patient eligibility

About

The goal of this observational study is to evaluate the levels of Antithrombin III, Protein C, Protein S, and D-dimer in patients with Acute Leukemia (Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML)). The main questions it aims to answer are:

What are the levels of Antithrombin III, Protein C, Protein S, and D-dimer in patients with Acute Lymphoblastic Leukemia? What are the levels of Antithrombin III, Protein C, Protein S, and D-dimer in patients with Acute Myeloid Leukemia? Researchers will compare patients with Acute Leukemia (30 with ALL and 30 with AML) to 30 healthy control subjects to see if there are significant differences in the levels of Antithrombin III, Protein C, Protein S, and D-dimer.

Participants will:

Undergo full history and clinical examination. Have routine hematological analysis including Complete Blood Count (CBC), blood film, Erythrocyte sedimentation rate (ESR), Prothrombin Time Test and INR (PT/INR), and partial thromboplastin time (PTT).

Have specific tests for quantitative measurement of Antithrombin III, Protein C, Protein S, and D-dimer.

Undergo Flow cytometry immunophenotyping.

Enrollment: 90 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. patients with leukemia in group 1 and 2.
2. willing to participate in the study.

Exclusion criteria

1. refusing to participate.
2. patients with know to have either hereditary thrombophilia or current thrombosis.

Trial design

90 participants in 3 patient groups

acute lymphoblastic leukemia

Description:

patients diagnosed with acute lymphoblastic leukemia.

Treatment:

Diagnostic Test: Antithrombin III

Diagnostic Test: Protein C

Diagnostic Test: Flow cytometry immunophenotyping

Diagnostic Test: D-dimer

Diagnostic Test: Protein S

acute myeloid leukemia

Description:

patients diagnosed with acute myeloid leukemia.

Treatment:

Diagnostic Test: Antithrombin III

Diagnostic Test: Protein C

Diagnostic Test: Flow cytometry immunophenotyping

Diagnostic Test: D-dimer

Diagnostic Test: Protein S

control group

Description:

controlled group include healthy persons not suffering from acute leukemia either clinically or laboratory

Treatment:

Diagnostic Test: Antithrombin III

Diagnostic Test: Protein C

Diagnostic Test: Flow cytometry immunophenotyping

Diagnostic Test: D-dimer

Diagnostic Test: Protein S