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Assessment of Autogenous Dentin Graft in Treatment of Infra-bony Defect

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October 6 University

Status

Completed

Conditions

Periodontitis (Stage 3)

Treatments

Procedure: Autogenous demineralized dentin nanoparticles

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The aim of the present study was to evaluate the effect of demineralized autogenous dentine on treatment of infrabony defects.

Full description

In this study, the investigators tested the effect of demineralized autogenous dentine as a bone graft in treatment of stage III periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, and bone gain in defect sites.

Enrollment

20 patients

Sex

All

Ages

16 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with good systemic health and no contraindication for periodontal surgery.
  • Patients who are able to maintain good oral hygiene.
  • Gingival thickness for the site selected should be ≥1mm.
  • Probing depth of ≥ 6mm.
  • Patient has at least one hopeless teeth

Exclusion criteria

  • Active infectious diseases (hepatitis, tubercu¬losis, HIV, etc....).
  • Medically compromised patients.
  • Smokers and alcoholic abusers
  • People who suffer from any systemic disease that affect the periodontium.
  • Pregnant, postmenopausal women.
  • People who take anti-inflammatory drugs, anti¬biotics or vitamins within the previous 3 month.
  • People who use mouth washes regularly
  • Participants in other clinical trials.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

20 participants in 2 patient groups, including a placebo group

Open flap debridement + allograft bone (Maxgraft)
Placebo Comparator group
Treatment:
Procedure: Autogenous demineralized dentin nanoparticles
Open flap debridement + Autogenous demineralized nanoparticles
Active Comparator group
Treatment:
Procedure: Autogenous demineralized dentin nanoparticles

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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