Assessment of Autonomic Neuronal Changes During Moderate Rise of Intracranial Pressure in Human (CESNA)

Toulouse University Hospital

Status: Completed

Conditions: Increased Intracranial Pressure Disorders

Treatments: Other: Infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT01776801

07 299 03

Details and patient eligibility

About

The purpose of this project is to determine during moderate rise of intracranial pressure (ICP) in awake patient, the change in autonomic function and its influence on cerebral and systemic haemodynamics.

Full description

From preliminary data, we know that changes in ICP influences both systemic and cerebral haemodynamics, introducing the concept of intracranial baroreflex We have to i) confirm the presence of this intracranial baroreflex, ii) analyze the changes in autonomic function during moderate rise in intracranial pressure (ICP) in human, and iii) correlate the changes in cerebral and systemic haemodynamics with autonomic function.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient suspect of hydrocephalus with gait problems, urine incontinence and mild cognitive impairment.
• signed consent

Exclusion criteria

• psychiatric problems
• severe cognitive decline

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Hydrocephalus

Experimental group

Description:

Patients suffering of hydrocephalus (cognitive impairment, gait disturbance, urinary incontinence and enlargement of the ventricles) require for clinical purpose infusion studies i.e. injection of mock cerebrospinal fluid (CSF) in the sub arachnoid space to artificially increase ICP. We aim at using infusion studies as a indirect tool to assess whether a moderate increase in ICP has any influence on haemodynamics.

Treatment:

Other: Infusion