Assessment of Bioavailability of Phenolics From an Orange Peel Extract

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Improving Bioavailability

Treatments: Dietary Supplement: phenolics form orange peel

Study type: Interventional

Funder types: Other

Identifiers

NCT02033330

Cordiart-PKA-1

Details and patient eligibility

About

In this study, the bioavailability of a specific orange peel extract is tested. The composition and morphology of the test product is altered compared to the generic product, which is used as a control. Due to intellectual property issues, more information cannot be given at this moment. Also the difference in bioavailability between a capsule and a lozenge is tested. The hypothesis is that the bioavailability of the altered extract will be improved compared to the control.

Enrollment: 11 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adults
• BMI 18.5 to 25

Exclusion criteria

• pregnancy
• smoking
• alcohol or drug abuse
• use of medication
• use of nutritional supplements
• abnormal liver or kidney function

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

11 participants in 3 patient groups

phenolics form orange peel, type 1

Active Comparator group

Description:

1 dose of 500 mg of phenolics from orange peel, orally ingested

Treatment:

Dietary Supplement: phenolics form orange peel

phenolics from orange peel, type 2

Active Comparator group

Description:

1 dose of 500 mg of phenolics from orange peel, orally ingested

Treatment:

Dietary Supplement: phenolics form orange peel

phenolics from orange peel, type 3

Experimental group

Description:

1 dose of 500 mg of phenolics from orange peel, orally ingested

Treatment:

Dietary Supplement: phenolics form orange peel