Assessment of Blood Pressure Control and Target Organ Damage in Patients With Chronic Kidney Disease and Hypertension -II

Seoul National University

Status: Unknown

Conditions: Chronic Kidney Disease; Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT02078115

APRODITE-2

Boryung (Other Grant/Funding Number)

Details and patient eligibility

About

The purpose of this study is to find the change of blood pressure (BP) control pattern (true controlled, white-coat, masked, and sustained uncontrolled/ dipper, non-dipper, reverse-dipper, and extreme-dipper) in patients with chronic kidney disease (CKD) over 3 years. And Other objective is the relationship between the BP control pattern and the target organ damages such as renal function, proteinuria, left ventricular hypertrophy (LVH), and so on. In addition, we will find clinical factors related to the BP control pattern.

Enrollment: 400 estimated patients

Sex: All

Ages: 20 to 74 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. with informed consent
2. 20 <= age < 75 years
3. diagnosed as hypertension 6 months (or 3 visits) prior to enrollment, taking anti-hypertensive drugs over 3 months
4. all-cause chronic kidney disease patients with 15 <= estimated GFR < 90
5. no change of anti-hypertensive drugs within 2 weeks and good compliance

Exclusion criteria

1. changed prescription according to ambulatory blood pressure monitoring (ABPM) regularly
2. had acute kidney injury/hospitalization
3. had a proteinuria of > 6 g/day (spot urine protein to creatinine ratio > 6.0 g/g Cr)
4. had end stage renal disease (ESRD) with dialysis and/or were a kidney recipient
5. had diseases, such as uncontrolled arrhythmia, uncontrolled bronchial asthma/chronic obstructive pulmonary disease, or primary endocrinologic diseases except diabetes mellitus
6. were pregnant/lactating women
7. were night shift workers.

Trial design

400 participants in 1 patient group

chronic kidney disease, hypertension

Description:

20 \<= age \< 75 years 15 \<= estimated glomerular filtration rate (GFR) \< 90