Assessment of Bone Mineral Density During Pregnancy

Ain Shams University

Status and phase: Completed; Phase 1

Conditions: Bone Mineral Density Quantitative Trait Locus 3

Treatments: Radiation: calcaneal quantitative ultrasound assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT02480023

osteopenia during pregnancy

Details and patient eligibility

About

BMD at peripheral sites typically heel is measured by Ultrasound densitometry at Ain Shams Maternity hospital.

Full description

Consecutive patients with singleton pregnancies between 36 and 39 weeks booked at a general obstetric clinic in a regional hospital will be recruited for the study. The obstetric department is a tertiary referral center in the region and part of a university teaching unit which catered to an annual delivery of around 10,000 women. A group of first trimester pregnant women with nearly the same age is recruited as controls.

Enrollment: 173 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. females during 3rd trimister

Exclusion criteria

1. Secondary causes of bone loss such as hyperparathyroidism.
2. Co-morbidities that would interfere with bone metabolism as clinically significant liver or renal disease.
3. Physical or orthopedic disabilities that would place the subject at risk or limit their ability to perform US.
4. Taking medication known to affect bone including steroid hormones.

Histories of smoking and use of oral contraceptives (OCs) are not exclusion criteria.

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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173 participants in 1 patient group

healthcare

Experimental group

Description:

QUS for calcaneus bone of right foot will be done for this group of Pregnant women at the third trimester

Treatment:

Radiation: calcaneal quantitative ultrasound assessment