Assessment of Bronchial Obstruction in Adolescents With HIV (ResppedHIV)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: HIV

Treatments: Diagnostic Test: pulmonary function tests

Study type: Interventional

Funder types: Other

Identifiers

NCT05869084

APHP211566

IDRCB: 2021-A02635-36 (Registry Identifier)

Details and patient eligibility

About

In children, data from the literature find a higher prevalence of asthma in the population treated for HIV. Bronchial hyperreactivity, indicative of chronic inflammation and bronchial obstruction, is also present.

Screening for early peripheral obstruction could therefore make it possible to initiate appropriate anti-inflammatory treatment, if necessary, and early preventive management.

Full description

In adults chronically infected with HIV, there is an increased prevalence impaired respiratory function, with a greater occurrence of COPD than in the uninfected population. In children, data from the literature find a prevalence of greater atopy in the HIV-infected pediatric population. Furthermore, a bronchial hyperreactivity or even peripheral bronchial obstruction, indicative of a local chronic inflammation has been found in young adolescents treated since the birth for HIV infection in utero. Screening for early peripheral obstruction in HIV-infected adolescents could therefore make it possible to initiate, if necessary, a anti-inflammatory treatment, and early management to prevent the occurrence of impaired respiratory function in adulthood For this this single-center prospective study chose to perform respiratory function explorations with forced oscillometry with the Endpoint main factor of the peripheral obstruction the R5HZ parameter expressed in % predicted. Patients from 11 to 25 years to whom it was proposed added to that to answer a questionnaire of respiratory quality of life

Enrollment: 21 patients

Sex: All

Ages: 11 to 25 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Children over 11 and Under 25-year-old infected with HIV and on antiretrovirals and followed up at Robert Debré hospital for this pathology
• Consent of the holders of parental authority and Patients informed and not objecting to participate in research Exclusion Criteria : •
• Age ≤ 11 years old
• Not treated for HIV
• Patients under guardianship / curatorship

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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21 participants in 1 patient group

pulmonary function tests

Experimental group

Treatment:

Diagnostic Test: pulmonary function tests