Assessment of CAI in Adults With PWS.

Medical University of Warsaw

Status

Completed

Conditions

Central Adrenal Insufficiency

Prader-Willi Syndrome

Study type

Observational

Funder types

Other

Identifiers

NCT04700644

CAIPWS

Details and patient eligibility

About

Introduction: The prevalence and clinical significance of central adrenal insufficiency (CAI) in adult patients with Prader Willi Syndrome (PWS) remains unclear.

Aim: To assess the prevalence of CAI in adults with PWS and to analyse the effects of replacement therapy with hydrocortisone (HCT) in patients with suspected CAI.

Material and Methods: Twenty one adult patients with PWS were evaluated. Based on peak cortisol at the 30 minute of the high dose short Synacthen test (HDSST), patients were divided into three groups: CAI (central adrenal insufficiency) - peak cortisol <500nmol/L, intermediate (partial AI) - peak cortisol ≥500 nmol/L and <600 nmol/L and AS (adrenal sufficiency) - peak cortisol ≥ 600 nmol/L. In patients with diagnosed CAI HCT replacement treatment was initiated. Body weight, body fat percentage, signs, and symptoms of CAI were evaluated after 6 and 12 months of treatment.

Enrollment

21 patients

Sex

All

Ages

18 to 26 years old

Volunteers

No Healthy Volunteers

Inclusion criteria