Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood (SALTO-SNA)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Sequels; Complications; Cancer; Autonomic Nervous System

Treatments: Other: Autonomic nervous system activity records

Study type: Observational

Funder types: Other

Identifiers

NCT01574196

1108162

2011-A01357-34 (Other Identifier)

Details and patient eligibility

About

The SALTO-SNA study is an ancillary study of the SALTO study (Suivi À Long Terme en Oncologie des enfants guéris d'un cancer pédiatrique en régions Rhône-Alpes et Auvergne) coordinated by Dr. Claire Berger, pediatric oncologist at the CHU, Saint Etienne. It aims at re-examining, in their initial treatment center, all patients (a cohort of 495 patients alive in 2011), diagnosed between 1987 and 1992, and cured of childhood cancer (except leukemia) in the Rhône-Alpes and Auvergne regions.

The rationale for this study is based on the observation that although the survival rate of childhood cancers has now reached 75%, complications of chemotherapy and radiotherapy are high and greatly increase the risk of mortality in later years (estimated to be 14% in the literature).

The morbidity risk of chemotherapy and radiotherapy can be quantified by assessing the activity of the intrinsic cardiac autonomic regulation, which represents a powerful predictor of cardiovascular morbidity to the individual.

Full description

For this purpose, analysis of the cardiac RR variability is a reliable, non-invasive and reproducible system that could be used in this population as a tool for early detection of cardiovascular dysfunction.

Enrollment: 83 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Included in the SALTO study
• Having signed the informed consent form

Exclusion criteria

• General anesthesia in the two weeks prior to recording
• Known allergy to electrodes

Trial design

83 participants in 1 patient group

Young adult survivors of childhood cancer

Description:

Young adult survivors of childhood cancer diagnosed between 1987 and 1992 in the Rhône-Alpes and Auvergne regions of France.

Treatment:

Other: Autonomic nervous system activity records