Assessment of Change in Atherosclerotic Plaque by Serial CCTA (ACROSS)

Yonsei University

Status: Unknown

Conditions: Coronary Artery Disease; Coronary Arteriosclerosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors

Treatments: Drug: Atorvastatin

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT03414840

2017-2669-001

Details and patient eligibility

About

Assessment of Change in AtheROSclerotic Plaque by Serial CCTA (ACROSS) is designed as a prospective observational study which aim is to demonstrate the effect of statins on coronary atherosclerosis, assessed by quantitative analysis of CCTA.

Enrollment: 400 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent clinically indicated CCTA (index CCTA)
• Mild to moderate stenosis (25-69%) on CCTA
• ≥1 clinical risk factors (Smoking, HTN, HDL<40, Premature FHx, M ≥45, F ≥55) for CAD

Exclusion criteria

• Acute coronary syndrome (unstable angina or MI)
• Positive (not equivocal) stress test
• Contraindications to statin