Assessment of Colonic Epithelial Integrity With Mucosal Impedance

Vanderbilt University Medical Center

Status: Completed

Conditions: Inflammatory Bowel Diseases

Treatments: Diagnostic Test: mucosal impedance (MI) testing

Study type: Observational

Funder types: Other

Identifiers

NCT03165058

160534

Details and patient eligibility

About

In this study, the investigators propose to use mucosal impedance (MI), a minimally invasive technology, to detect mucosal damage (i.e. barrier dysfunction) based on mucosal conductivity changes in the colonic epithelium.

Full description

The intestinal epithelium functions to separate luminal contents from the interstitium. Increased intestinal permeability can represent compromise of the epithelium's integrity. Prior research has demonstrated that defects in intestinal barrier function are associated with inflammatory bowel disease (IBD) and increased intestinal permeability can be important in the maintenance of remission in IBD patients. There is currently not a convenient way to measure colonic epithelial barrier function in real time which could provide clinically relevant information .

Enrollment: 32 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men and women over the age of 18 with a diagnosis of IBD (Ulcerative Colitis or Crohn's Disease)
• Men and women undergoing screening colonoscopy (typical age would be 50 or greater but there are exceptions)

Exclusion criteria

• Age less than 18 years old
• Patients unable to give informed consent
• Patients with history of colonic surgeries
• Patients with history of colonic motility disorder

Trial design

32 participants in 2 patient groups

Inflammatory Bowel Disease

Description:

Patients undergoing standard of care colonoscopy for inflammatory bowel disease (IBD) surveillance will have a MI catheter sensor positioned along the mucosal wall to measure resistance across the mucosa.

Treatment:

Diagnostic Test: mucosal impedance (MI) testing

control

Description:

Patients undergoing standard of care colonoscopy for age appropriate screening will have a MI catheter sensor positioned along the mucosal wall to measure resistance across the mucosa.

Treatment:

Diagnostic Test: mucosal impedance (MI) testing