Assessment of Complete Response MRI Criterion After Neoadjuvant Therapy in Locally Advanced Rectal Cancer

C

Centre Hospitalier Universitaire de Nīmes

Status

Completed

Conditions

Rectal Neoplasms

Study type

Observational

Funder types

Other

Identifiers

NCT05534841
22.03.05

Details and patient eligibility

About

Standard care for locally advanced rectal cancer consists in a neoadjuvant therapy followed by surgery. Morbidity and mortality remain high after rectal surgery, and often linked with quality of life impairment. 10 to 30% present a pathological complete response after neoadjuvant therapy. Some surgical teams propose "watch and wait" approach for patients selected with clinical complete responses criterion. The problem is to be sur the response is complete. MRI seems to be accurate to select complete responders. We will try to find MRI criterion of complete responses.

Enrollment

99 patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • Rectal adenocarcinoma
  • Locally advanced
  • Neoadjuvant therapy
  • MRI restaging
  • Rectal surgery
  • Definitive anatomopathology study

Trial design

99 participants in 2 patient groups

Pathological complete response
Description:
Patients with a complete response to the neoadjuvant therapy on the definitive anatomopathology study.
Non pathological complete response
Description:
Patients without complete response to the neoadjuvant therapy on the definitive anatomopathology study.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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