Assessment of Coronary Endothelial Function in Diabetic Patients With Acute Coronary Syndrome Using 15O-water Positron Emission Tomography (D-TEP)

Caen University Hospital

Status

Completed

Conditions

Myocardial Infarction

Treatments

Other: Coronary endothelial function measurements by quantitative method (TEP at 15O-H2O)

Study type

Interventional

Funder types

Other

Identifiers

NCT02510703

09-085

Details and patient eligibility

About

Type 2 diabetes is associated with early and diffuse abnormalities of endothelial function, especially in the coronary arteries, which are a factor of poor prognosis. Following acute coronary syndrome, the endothelial function abnormalities usually persist for several weeks before regressing. Their persistence 6-8 weeks after myocardial infarction is a poor prognostic factor. Investigators assume that global abnormalities of endothelial function in patients with diabetes may be additive with segmental abnormalities in revascularized myocardium, and contribute to worsening the prognosis in these patients. Furthermore, there is no published data showing any relationship between calcium score and endothelial function abnormalities in these patients. The investigators seek a relationship between calcium score and persistence of abnormalities of coronary endothelial function in these patients.

The main objective of this study was to compare coronary endothelial function by quantitative method (TEP at 15O-H2O) in diabetic patients and nondiabetic following acute coronary syndrome.

Enrollment

40 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with a first myocardial infarction, type 2 diabetic or non-diabetic treated by angioplasty in acute phase (TIMI 3)
Myocardial viability test before discharge
Age over 18 years
Informed Consent dated and signed by the patient
Written and spoken French
Beneficiary of social security insurance

Exclusion criteria

Hypertension> 160/90 mmHg despite medical treatment
Lack of effective revascularization in acute phase of myocardial infarction (TIMI grade <3)
Significant three-vessel coronary artery disease (> 70% stenosis in the other two coronary arteries); occlusion of a coronary artery; schedule revascularization (percutaneous or surgical); left main coronary artery stenosis
Previous history of myocardial infarction
Mechanical complication (mitral regurgitation, ventricular septal rupture, left ventricular free wall rupture)
Heart failure
No myocardial viability test before discharge, for whatever reason
Type 1 diabetes
Pregnant and / or lactating
Age under 18 years or guardianship