Assessment of Diaphragmatic Mobility in Dyspneic Patients With Different Types of Interstitial Lung Diseases

Ain Shams University

Status: Completed

Conditions: Diaphragm Issues

Treatments: Other: daiphragm mobility by ultrsound; Other: spirometry ,DLCo

Study type: Observational

Funder types: Other

Identifiers

NCT07131072

FMASU R13/2021

Details and patient eligibility

About

dyspnea and impaired exercise capacity in IPF patients can be related, at least in part, to respiratory muscle dysfunction, in particular to diaphragm functionality. Both B-mode and M-mode ultrasound techniques have been employed to assess diaphragm excursion, which measures the distance that the diaphragm is able to move during the respiratory cycle.

recent study using lung ultrasound in assessment of diaphragmatic mobility in IPF patients and found that Diaphragmatic mobility is lower in IPF patients than in healthy controls, especially during deep inspiration. The correlation between reduced FVC and diaphragmatic excursion values in IPF patients can be of interest, since it could represent an index of functional respiratory affection performed by chest ultrasound

Full description

Interstitial lung diseases are known to be associated with limitations in daily activities and impaired quality of life. One of the most troublesome burdens for ILD patients is dyspnea during exercise, which extends to the resting state as the disease advances. The causes of dyspnea are suggested to be a progressive decline in total lung capacity (TLC) and vital capacity, along with impairment of diffusion capacity and subsequent development of (primarily hypoxic) respiratory failure along with respiratory muscle dysfunction.

Studies have supported the advantage of ultrasonography in the assessment of diaphragmatic mobility by two-dimensional (BD) or M-mode. Others reported the investigation methods, the criteria for normal and pathological diaphragmatic function, and the perspectives of development in adult patients.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients presented to Ain Shams University Hospital outpatient clinic by ILD due to any cause

Exclusion criteria

• Pregnant females
• Patients with end stage organ failure e.g.: Renal failure, liver cell failure
• Patients with malignancy elsewhere.
• The patients who refuse to be entitled in the study.

Trial design

100 participants in 3 patient groups

collagen related interstitial lung disease

Treatment:

Other: spirometry ,DLCo

Other: daiphragm mobility by ultrsound

idiopathic type (IPF)

Treatment:

Other: spirometry ,DLCo

Other: daiphragm mobility by ultrsound

OTHERS(occupational,sarcoid,...)

Treatment:

Other: spirometry ,DLCo

Other: daiphragm mobility by ultrsound