Assessment of Different Orthodontic Tooth Movements Assisted With Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin

A

Al-Azhar University

Status and phase

Invitation-only
Phase 1

Conditions

Injectable Plasma-rich Fibrin Versus Low-Level Laser Therapy on Othodontic Movement

Treatments

Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin

Study type

Interventional

Funder types

Other

Identifiers

NCT05966987
923/91

Details and patient eligibility

About

The present prospective clinical study will be undertaken for assessment of the effect of application of Injectable plasma-rich fibrin versus Low-Level Laser Therapy onthe rate of different orthodontic tooth movements,

Full description

The present prospective clinical study will be undertaken for assessment of the effect of application of Inject able plasma-rich fibrin versus Low-Level Laser Therapy on the rate of different orthodontic tooth movements, namely: canine retraction, mandibular incisors leveling and alignment, maxillary molar distalization and maxillary incisor intrusion.

Enrollment

82 estimated patients

Sex

All

Ages

15 to 22 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

A- leveling and alignment Eligibility criteria

  • Complete permanent dentition (third molars not included).
  • Moderate mandibular anterior crowding (with Little's irregularity index score greater than 4 mm) who required nonextraction approach in the mandibular arch.
  • No tooth size, shape or root abnormalities visible on patient's radiographic records.
  • No spaces in the mandibular arch.
  • No blocked out tooth that did not allow for placement of the bracket at the initial bonding appointment.

No required management with interproximal stripping, intermaxillary elastics, open NiTi springs, and removable or extra-oral devices. Maxillary molar distalization Inclusion criteria:

1. Age ranges from 14 to 17 years. 2. Bilateral Class II molar relationship. 3. Skeletal Class I or mild Class II relationship. 4. Normal or decreased vertical height. 5. No posterior crowding or spaces. 6. Fully erupted maxillary first and second molars. 7. Congenitally missing or extracted third molars. 8. Good oral hygiene. 9. Absence of any periodontal disease and alveolar bone loss. 10. Absence of medications that may inhibit orthodontic movement

Lower incisor leveling and alignment Inclusion criteria

  • Complete permanent dentition (third molars not included);
  • Moderate mandibular anterior crowding (with little's irregularity index score greater than 4 mm) who required non-extraction approach in the mandibular arch;
  • No tooth size, shape or root abnormalities visible on the patient's radiographic records;
  • No spaces in the mandibular arch;
  • No blocked out tooth that did not allow for placement of the bracket at the

initial bonding appointment; 6. No required management with interproximal stripping, inter-maxillary elastics, open NiTi springs, and removable or extra-oral devices. Canine retraction Eligibility criteria

  • Age, 15 to 25 years;
  • Class ii division 1 malocclusion with mild or no crowding;
  • No previous orthodontic treatment;
  • No systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency;
  • Adequate oral hygiene;
  • Probing depth values not exceeding 3 mm across the
  • Entire dentition;
  • Adequate thickness of the attached gingiva (1-2 mm);
  • No radiographic evidence of bone loss

Exclusion Criteria:Exclusion criteria:

  • Patients who required surgery to correct skeletal discrepancies.
  • Patients with congenital dentoskeletal disorders.
  • Missed or mutilated teeth in maxillary arch.
  • Patients with poor oral hygiene and/or periodontally compromised patients Severe dental crowding that necessitates an extraction approach 2. Abnormal anteroposterior and vertical relationships; 3. Patients with cleft lip and palate, anomalies, and syndromes; 4. Previous orthodontic 5. Treatment; 6. Regular medications intake that could interfere with otm. -

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Factorial Assignment

Masking

None (Open label)

82 participants in 14 patient groups

i-PRF side: canine retraction
Experimental group
Description:
application of i-PRF with translation of maxillary canine that will be performed on intervention sides according to a standardized protocol
Treatment:
Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
i-prf side control side
No Intervention group
Description:
i-PRF side:canine retraction control side
LLLT side canine retraction
Experimental group
Description:
translation of maxillary canine that will be performed with LLLT application according to a standardized protocol
Treatment:
Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
LLLT side canine retraction control side
No Intervention group
Description:
LLLT side canine retraction control side wihout intervention
I-PRF groupMolar distalization group inrervention side
Experimental group
Description:
Idistalization assisted with Injectable platelet-rich fibrin (i-PRF) according to a standardized protocol
Treatment:
Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
I-PRF groupMolar distalization group control side
No Intervention group
Description:
distalization without i-PRF intervention
LLLT group: distalization intervntion side
Experimental group
Description:
distalization will be commenced with application of LLLT according to a standardized protocol
Treatment:
Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
LLLT group: distalization control side
No Intervention group
Description:
distalization will be commenced without application of LLLT according to a standardized protocol
i-PRF group: leveling and alignment
Experimental group
Description:
leveling and alignment assisted with Injectable platelet-rich fibrin (i-PRF) according to a standardized protocol
Treatment:
Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
LLLT group: leveling and alignment
Experimental group
Description:
leveling and alignment be commenced with application of LLLT according to a standardized protocol
Treatment:
Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
leveling and alignment without intervention
No Intervention group
Description:
leveling and alignment without intervention
I-PRF group: Intrusion
Experimental group
Description:
intrusion assisted with Injectable platelet-rich fibrin (i-PRF) according to a standardized protocol
Treatment:
Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
LLLT group: Intrusion
Experimental group
Description:
intrusion assisted with application of LLLT according to a standardized protocol
Treatment:
Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
intrusion control group
No Intervention group
Description:
intrusion without intervention

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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