Assessment of Dimensional Changes Following Grafting With Microfragmented Adipose Tissue Loaded on Allograft on Ridge Preservation

Cairo University (CU)

Status: Not yet enrolling

Conditions: Hopeless Tooth

Treatments: Procedure: microfragmented adipose tissue loaded on allograft

Study type: Interventional

Funder types: Other

Identifiers

NCT06636461

Assessment of dimensional chan

Details and patient eligibility

About

Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by radiographic and Histomorphometry ) utilizing microfragmented adipose tissue loaded on allograft versus allograft only for maxillary posterior ridge preservation

Full description

All patients involved in this study will be divided into two groups; each group will receive a different graft of bone augmentation: Adipose tissue loaded on allograft will be utilized for the study group and allograft only for the control group.

After 3-6 months, assessment of dimensional changes ( RG height & width) on CBCT is performed and Histomorphometry will be evaluated via core biopsy at the time of implant placement in both groups.

Radiographic assessment that will be achieved by CBCT scan will be used to calculate the changes of bone height and width from base line (1week) to 3-6 months postoperatively.

Enrollment: 26 estimated patients

Sex: All

Ages: 21 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients requiring implant treatment after tooth extraction due to either unrestorable caries lesions or affected periodontium.

Age group: above 18 years

• Remaining natural teeth have good periodontal tissue support and occlusion showed sufficient inter arch space for future prosthesis.

Exclusion criteria

• • General contraindications to implant surgery.

  • Subjected to irradiation in the head and neck area less than 1 year before implantation.
  • Poor oral hygiene and motivation.
  • Severe bruxism or clenching.
  • Systemic, immunologic or debilitating diseases that could affect normal bone healing & local pathosis.
  • Treated or under treatment of intravenous amino-bisphosphonates.
  • Active infection or severe inflammation in the area intended for implant placement.
  • Patients participating in other studies, if the present protocol could not be properly followed.
  • Heavy somkers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

26 participants in 2 patient groups

microfragmented adipose tissue

Experimental group

Description:

microfragmented adipose tissue loaded on allograft on ridge preservation

Treatment:

Procedure: microfragmented adipose tissue loaded on allograft

allograft

Active Comparator group

Description:

allograft only on ridge preservation

Treatment:

Procedure: microfragmented adipose tissue loaded on allograft