Assessment of Dried Blood Spot Thyroglobulin and Urinary Iodine Concentration in Pregnant Women (STRIPE)

Federal Institute of Technology (ETH) Zurich

Status: Completed

Conditions: Pregnancy Related; Iodine Deficiency

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03176706

STRIPE

Details and patient eligibility

About

To avoid iodine deficiency and its consequences in pregnant women and their offspring, women should reach a sufficient iodine intake long before conception. To monitor iodine status, median urinary iodine concentration (UIC) is widely used in pregnant women (PW). Thyroglobulin (Tg) us another marker used to assess iodine status . In this study, urine samples as well as dried blood spots will be collected to measure UIC and Tg (as well as other hormones to define thyroid function) in PW. The results shall be used to reassess the threshold which defines iodine status in PW according to UIC.

Enrollment: 2,900 patients

Sex: Female

Ages: 18 to 44 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Generally healthy
2. No major medical illness, no thyroid disease, and taking no chronic medication
3. No use of iodine containing dietary supplements
4. No use of iodine-containing X-ray /CT contrast agent or iodine containing medication within the last year
5. Aged between 18 and 44 at enrollment
6. Singleton pregnancy
7. Non-smoking
8. Residence at study site since 12 months or longer

Trial design

2,900 participants in 7 patient groups

Lebanese pregnant women

Description:

Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in the Lebanon.

Treatment:

Other: no intervention

Thai pregnant women

Description:

Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in Thailand.

Treatment:

Other: no intervention

South African pregnant women

Description:

Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in South Africa.

Treatment:

Other: no intervention

New Zealand pregnant women

Description:

Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in New Zealand.

Treatment:

Other: no intervention

Swedish Pregnant women

Description:

Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in Sweden.

Treatment:

Other: no intervention

Peruvian pregnant women

Description:

Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in Peru.

Treatment:

Other: no intervention

Russian pregnant women

Description:

Pregnant women which are suspected to have mild to moderate iodine deficiency but are otherwise health and living in Russia.

Treatment:

Other: no intervention