Dry Eye Disease With Isotretinoin ISOTRETINOIN

Cairo University (CU)

Status: Not yet enrolling

Conditions: Acne Vulgaris

Treatments: Diagnostic Test: Ocular Surface Disease Index (OSDI) questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT06725290

Dry eye with isotretinoin

Details and patient eligibility

About

The study aims to explore the effects of isotretinoin therapy on the dry eye parameters in acne vulgaris patients & determine if it is dose-dependent or not.

Full description

To measure the tear film, the eye lid thickness, the meibomian gland function and to do objective tests for comparison

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Moderate to severe acne on isotretinoin

Exclusion criteria

• Occular diseases causing dry eye
• Pregnant females

Trial design

60 participants in 3 patient groups

low dose isotretinoin

Description:

Acne patients taking 20 mg daily isotretinoin

Treatment:

Diagnostic Test: Ocular Surface Disease Index (OSDI) questionnaire

high dose isotretinoin

Description:

Acne patients taking 0.5 mg/kg daily dose of isotretinoin

Treatment:

Diagnostic Test: Ocular Surface Disease Index (OSDI) questionnaire

Normal control

Treatment:

Diagnostic Test: Ocular Surface Disease Index (OSDI) questionnaire