Assessment of Early Treatment Response by Diffusion and Perfusion MRI in Patients With Brain Metastasis

Memorial Sloan Kettering Cancer Center (MSK)

Status: Completed

Conditions: Brain Cancer

Treatments: Procedure: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT01974804

13-094

Details and patient eligibility

About

Magnetic resonance imaging (MRI) is a diagnostic study that makes pictures of organs of the body using magnetic field and radio frequency pulses that can not be felt. The purpose of this study is to determine if new imaging methods can help tumor evaluation in the brain. The extra images will be obtained using diffusion and perfusion MRI techniques to assess early treatment response in patients with brain metastasis, and will be compared to methods currently being used.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 18 and over.
• Patients/Subjects able to give informed consent
• Patients/Subjects whose weight does not exceed 275 lbs.
• Patient with metastatic brain tumors greater than or equal to 1.0 cm that will be treated with stereotactic radiosurgery and scheduled for an MRI scan as part of their routine care

Exclusion criteria

• Patients who are unwilling or unable to undergo MRI including patients with contra-indications to MRI such as the presence of cardiac pacemakers or non-compatible intracranial vascular clips.

Trial design

30 participants in 1 patient group

Pts having an MRI

Description:

Patients will undergo a 20 minute pretreatment MRI scan and a 30 minute post treatment MRI scan with contrast agent administration. Ten patients with brain metastasis will be recruited in the study. All the patients will be undergoing SRS (Stereotactic Radiosurgery). Patients will have 1 pretreatment evaluation and 2 post treatment evaluations \[1-72 hours post treatment and 8 weeks (+/- 2 weeks) post treatment\] for early response. Patients are to be administered contrast prior to obtaining MRI scans. These research scans are estimated to take 20 minutes of scan time (+/- 10 minutes), which includes patient set up and conducting the research sequences..

Treatment:

Procedure: MRI