Assessment of EGFR Genomic Alterations as Prognostic Markers in Cervical Cancer

University of New Mexico (UNM)

Status: Withdrawn

Conditions: Cervix; Cervical Cancer

Treatments: Genetic: Tissue Repository

Study type: Interventional

Funder types: Other

Identifiers

NCT00298064

INST 0548C

Details and patient eligibility

About

The Tissue Repository will search for cases, pull slides, Paraffin-embedded tissue (PET) blocks.

Full description

This study is done to gather preliminary data for determining the best way to test EGFR expression in patients with cervical cancer who will receive treatment with EGFR inhibitors in the future.

This study is designed to obtain preliminary data of genomic and phenotypic alterations of the EGFR pathway in high grade cervical intraepithelial lesions (HG-SIL) and invasive cervical cancers (CC) to be used later for therapeutic guidance and to evaluate genomic (over-expression, amplification, point mutations, etc.) and phenotypic alterations of other transduction pathways interacting with the EGFR pathway.

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• Samples from patients diagnosed with HG-SIL (n=300) and CC (n=300) with a follow-up of at least 24 months, existing at the Department of Pathology will be retrieved by the Tissue Repository, de-identified them and provided with code numbers that will not be linked to patient's data.

Exclusion criteria

• None Specified.